Chromatography resins are medias that are made up of cellulosic matrix used to aid chromatography process such as immobilization of biomolecules and purification of antibodies. Hydrophobic interaction resins, multimodal resins, size exclusion resins, and affinity resins are some examples of chromatographic resins that are available in the market.
The global chromatography resins market size was valued at $2.1 billion in 2020, and is projected to reach $4.1 billion by 2030, growing at a CAGR of 7.1% from 2021 to 2030.
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Affinity chromatography resins are selective and effective resins that are widely used for antibody purification. In addition, these are also employed during purification of recombinant monoclonal antibody and bio-processing applications. Capturing of Fabs, dAbs, and single-chain fragment variable (scFv) antibody fragments using affinity resins containing agarose matrix is the key market trend.
“Statement for COVID-19 banner: Protein A derived chromatography resins are employed to overcome purification challenges that occur during development of coronavirus vaccines. For instance, Navigo and Repligen team have developed affinity resins that are used downstream processing (DSP) owing to its ability to escalate the purification speed and yield high quality COVID-19 vaccine.”
The chromatography resins market is segmented on the basis of type, application, and region. On the basis of type, the market is categorized into hydrophobic interaction resin, multimodal or mixed-mode resin, size exclusion resin, affinity resin, ion-exchange resin, and others. By application, the market is divided into antibody purification, biomolecule separation & purifications, vaccination, and others. Region wise, the market is studied across North America, Europe, Asia-Pacific, and LAMEA.
Impact Of Covid-19 On The Global Chromatography Resins Market
- The novel coronavirus is an incomparable global pandemic that has spread to over 180 countries and caused huge losses of lives and the economy around the globe. The chromatography resins market has been positively impacted due to the wake of the COVID-19 pandemic, owing to its dependence on biomolecule separation & purifications, vaccination, and protein separation application.
- Protein A derived chromatography resins are employed to overcome purification challenges that occur during development of coronavirus vaccines. For instance, Navigo and Repligen team have developed affinity resins that are used downstream processing (DSP) owing to its ability to escalate the purification speed and yield high quality COVID-19 vaccine.
- Navigo has developed protein A affinity resins that are developed or captured using spike protein from coronavirus. In addition, Repligen will offer chromatography beads that in turn enhances generation of high quality spike protein A affinity resins.
- COVID-19 vaccines are based on recombinant protein and production involves several challenges in DSP process. For instance, low concentration and high background capacity of host cell proteins make these vaccine production and purification a time consuming and high cost production steps. In addition, primary DSP steps includes chronological chromatography steps, manufacturers need to handle large volumes of liquid, and every protein vaccine requires newly developed-from-scratch DSP. Thus, to overcome these problems, vaccine manufacturers are following affinity chromatography techniques which in turn is escalating the demand of chromatographic resins amid COVID-19 pandemic.
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By application, the antibody purification segment dominated the global market in 2020, and is anticipated to grow at a CAGR of 7.4% during forecast period. Antibody purification process involves isolation antibodies from fluid pool such as polyclonal antibody or ascites fluid in order to obtain usable antibodies. Different chromatography resins are used depending upon the purification level of antibodies and its intended application
Protein A, Protein G, Protein A/G, and Protein L are types of affinity resins that are widely used chromatography resins for addressing and solving challenging downstream procedures of next-generation antibody purification and therapeutics. Protein A chromatography resins does not yield optimal results during capturing and purification of antibody modalities. However, unique selectivity of affinity chromatography resins makes it suitable resin compounds during antibody therapeutic process is the key market trend
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Key benefits for stakeholders
- Porter’s five forces analysis helps analyze the potential of buyers & suppliers and the competitive scenario of the industry for strategy building.
- It outlines the current market trends and future estimations of global chromatography resins market from 2020 to 2030 to understand the prevailing opportunities and potential investment pockets.
- The major countries in the region have been mapped according to their individual revenue contribution to the regional market.
- The key drivers, restraints, and opportunities and their detailed impact analysis are explained in the study.
- The profiles of key players and their key strategic developments are enlisted in the report.
The major companies profiled in this report
Cytiva Lifesciences, Bio-Rad Laboratories Inc., Sartorius AG, Generon, Tosoh Bioscience, Bio-Works, Repligen Corporation, LAF-Biotechnology, JNC Corporation, and Anatrace Products LLC.
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